“Heat” Cancer Cells to Death- Interview Li Zhigang, Director of the Precision Medicine Center of Hainan Chengmei Hospital

Release time:2022-08-04
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"I felt like the cancer cells in my stomach were ‘being burned to death’.” On August 2, Ms. Wang, who had just completed the third thermoperfusion treatment, said with joy on her face.

Ms. Wang carried out thermoperfusion treatment in Hainan Chengmei Hospital for three times, and ascites has quietly "disappeared” and tumor markers have dropped to about 7,000 now from 60,000 before treatment. Ms. Wang said happily: "Now I feel relaxed, thanks to the introduction of thermoperfusion therapy technology in Hainan Chengmei Hospital, which has brought new life to us tumor patients who have metastasized with membrane implantation.”

In May this year, the Precision Medicine Center of Hainan Chengmei Hospital introduced the body cavity thermal perfusion treatment system, and successfully carried out thermal perfusion treatment for several patients with refractory ascites. All patients who received treatment reported that the control of ascites was very obvious.

Li Zhigang, Director of the Precision Medicine Center of Hainan Chengmei Hospital, said that for tumor patients like Ms. Wang who have metastasized with membrane implantation, conventional surgery, radiotherapy, chemotherapy and immunization, while the effects are often unsatisfactory. From the clinical point of view, the body cavity thermoperfusion technology introduced by the hospital can quickly relieve the patients condition and pain.

How are cancer cells scalded to death ?

People are afraid of heat, cancer cells are also "afraid". Studies have shown that normal cells in the human body can withstand the temperature of 47℃ for 1 hour, while malignant tumor cells can tolerate the temperature of only 43℃.

Li Zhigang introduced that body cavity thermoperfusion therapy is to use the characteristics of "heat” frightened of tumor cells, heat normal saline to 43 ° C and constant temperature cycle into the patients body cavity for an hour to scald cancer cells to death.

Meanwhile, in order to enhance the effectiveness of treatment, in the process of implementing thermoperfusion, chemotherapy drugs will be added according to 1/3 to 2/3 of the therapeutic dose, under high temperature environment, the permeability of cancer cells is increased, it is easier for the drug to enter the inside of cancer cells, and the cancer cells are "precise" attacked, achieveing the purpose of "killing" cancer cells.

Advantages of thermoperfusion therapy

Li Zhigang introduced that for patients with late-stage peritoneal implantation metastasis, the treatment methods of conventional puncture and ascites and normal temperature injection of drugs in the abdominal thorax are not ideal, and the average survival time of patients is only 3 to 4 months.

"Compared with conventional treatment, thermoperfusion therapy has fewer side effects and complications, which can prolong the survival of patients and improve the quality of life of patients.” Li Zhigang summarized three advantages of body cavity hyperthermia therapy: First, the chemotherapy drugs added in hyperthermia therapy can directly act on tumor cells and increase the local drug concentration of the tumor; The second is the precise delivery of chemotherapy drugs through drainage tubes in thermoperfusion therapy would reduce the dose of chemotherapy drugs entering the human body from the venous channel, thereby reducing the side effects caused by chemotherapy drugs; Third, for the phenomenon of implantation and metastasis of existing tumor cells found during the operation, body cavity thermal perfusion can reduce the postoperative incidence of malignant ascites in the abdominal cavity and prolong the survival of patients.

Indications and contraindications of thermoperfusion therapy

At present, body cavity thermoperfusion therapy has been widely used in the treatment of abdominal and thoracic tumors (including stomach, colorectal tumors, gynecological tumors, lung cancer, hepatobiliary cancer, esophageal cancer, bladder cancer, and malignant ascites in the chest and abdomen, etc.).

Li Zhigang reminded that after the end of body cavity thermoperfusion treatment, patients need to receive high-energy fluids because of excessive sweating; Patients who can eat should drink more water, eat high-protein, high-vitamin food that is easy to digest; At the same time, increase the intake of milk and fruit, avoid fried and irritating food; Exercise properly and get enough rest.

Li Zhigang said that although body cavity hyperthermic chemotherapy has significant advantages, the following four types of patients are not suitable for the therapy: first, patients with severe abdominal adhesion and in high risk of intestinal tube damage; The second is to produce extensive adhesion, the formation of unbreakable separation, abdominal cavity volume less than 1000ml patients; Third, patients with obvious liver and kidney insufficiency, cardiopulmonary insufficiency, fever up to 38℃ and with unstable vital signs; Fourth, patients with abdominal inflammatory lesions or advanced tumor malignancy.

Li Zhigang introduced that at present, they have completed dozens of body cavity thermoperfusion treatment, and have reached the expected treatment goal.

Consultation for treatment details ►

Precision Medicine Center of Hainan Chengmei Hospital: 13627558011

Text from Huang Fei